Plesk support has a help page on that: https://support.plesk.com/hc/en-us/articles/12377562126743-MySQL-fails-to-start-when-a-Plesk-server-lacks-disk-space-SQLSTATE-HY000-No-space-left-on-device-500-Plesk-Exception-Database
Delete temporary files that are older than 14 days... # find /tmp -type f -mtime +14 -exec rm {} \; # find /var/tmp -type f -mtime +14 -exec rm {} \; # rm -rf /usr/local/psa/PMM/tmp/* /usr/local/psa/tmp/* Check the size and clean package cache... # du -sh /var/cache/apt/ # sudo apt-get clean To remove the oldest Plesk backup file... # /usr/local/psa/admin/bin/pmm-ras --get-dump-list --type=server | grep 'message' | grep -v [0-9]_[0-9]backup_info_2010230005.xml: backup_info_2010300005.xml: The first one in the output is the oldest one. Remove it using its name... # /usr/local/psa/admin/bin/pmm-ras --verbose --debug --delete-dump --dump-specification=backup_info_2010230005.xml --session-path=/var/log/plesk/PMM Find all files bigger than 200 MB size... # find / -type f -size +200M -exec du -h {} + 2>/dev/null | sort -r -h 248M /var/log/plesk-php74-fpm/error.log 218M /var/lib/mysql/ibdata1 There will be a log files among them like error.log in above example, you may clean them up... # echo > /var/log/plesk-php74-fpm/error.log # service plesk-php74-fpm restart Restart services... # service psa restart